Once the haunt of Jack the Ripper, London's East End is a vibrant mix of history and new ideas, but the trendy galleries of Brick Lane disguise a seedy underside where unthinkable crimes bring terror to the innocent. Artist and young mother Sandra Gilles disappears without trace after leaving her three-year-old daughter, Charlotte, with a friend at the Columbia Road Flower Market. Her lawyer husband, Naz Malik, is devastated but he's also the prime suspect in a murder investigation.

When Naz vanishes shortly afterwards, Gemma James and her partner Superintendent Duncan Kincaid agree to work together again to solve the case before the murderer can get his hands on the real prize, Charlotte. But just as the case grows more dangerous, a personal issue threatens to throw Gemma and Duncan off the trail. In the end, it is up to them to stop a vicious killer and protect the child whose fate hangs in the balance.